MAPTrix¢â Nanofiber Technology
Physical factor, a component of extracellular microenvironment, such as matrix mechanics and nanotopographical features of the extracellular matrix, can have strong influences on regulating cell functions.

Native extracellular matrix (ECM) contains fibrils range from tens of nanometers to micrometers in scale. The organized structure of these fibrous matrix guides tissue morphogenesis and remodeling.

In addition, matrix fibrils serve as ¡°depots¡± for the storage of bioactive factors for the regulation of cell migration, proliferation, and differentiation.

Therefore, ECM provides structure and mechanical integrity to tissues, as well as communicating with the cellular components it supports to help facilitate and regulate cell functions.

The advanced electrospinning technique is a promising tool to fabricate a controllable continuous nanofiber scaffold similar to the natural extracellular matrix.

Kollodis has developed MAPTrix¢â ECM based nanofiber technology with the highlighted features as follows:
  • 3D topography that mimics the in vivo topography
  • 3D microenviornment in terms of physical and biochemical factors
    - physical factor: fiber diameter, elasticity,
    - presentation of bioactive components such as ECM-derived adhesive ligand or growth factor
    - adhesive ligand density & sptial distribution
  • Spatiotemporal control of biochemcial & physical factors in nanofibrous matrix

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